Graduate students
The following students are currently participating in the Chemical Biology option:
January 2006 | ||
Trainee | Mentor | Research interest |
Sun, Yue | Nagar, Bhushan | Structural Analysis of the RET Tyrosine Kinase in Complex with Small Molecule Inhibitors |
Surprenant, Jamie | Thomas, David | Chemical Biological Approaches to New Antifungals |
September 2005 | ||
Trainee | Mentor | Research interest |
Acoca, Stephane | Purisima, Enrico | Application and Development of Computational Methods for Lead Discovery |
Bhagatji, Pinkesh | Silvius, John | K-ras4B Targeting and Signaling Studied using Chemically Induced Heterodimerization |
Corbeil, Christopher | Moitessier, Nicolas | Development and Application of New Tools for Virtual Screening |
Czerniewski, Alexandre | Bohle, Scott | Synthesis and Development of Novel Nitric Oxide-releasing Probes for Magnetic Resonance Imaging |
Freiburger, Lee | Auclair, Karine | The Study of Activators of Aminoglycoside N-6’ Acetyltransferase |
Linquist, Lisa | Pelletier, Jerry | A Chemical Biology Approach to Study Eukaryotic Translation Initiation |
Livingstone, Mark | Sonenberg, Nahum | Identification of Downstream Targets of the RACK-PKC-SAPK Signaling Pathway Affecting Translation of mRNA to Protein |
Rodionov, Dmitry | Herscovics, Annette | Structure-function studies of Fungal Mannosyltransferases Implicated in Virulence |
Yachnin, Brahm | Berghuis, Albert | X-Ray Crystallographic Analysis of Baeyer-Villiger Monooxygenases |
January 2005 | ||
Trainee | Mentor | Research interest |
Fan, Anna | Young, Jason | The Biochemistry of Tom70 |
Ngo, Thien-An | Cosa, Gonzalo | Development of a Fluorescence-based Liposome Microarray System for High Throughput Lipid Membrane Recognition Studies |
September 2004 | ||
Trainee | Mentor | Research interest |
Baettig, Oliver | Berghuis, Albert | Structural and Functional Analysis of Aminoglycoside 6’-N-Acetyltransferase-Ii |
Chefson, Amandine | Auclair, Karine | Study of the Effect of Organic Molecules on P450 Enzymes Activity |
Englebienne, Pablo | Moitessier, Nicolas | Improving Drug Design and Discovery through Molecular Modeling |
Hwang, Jiyoung | Berghuis, Albert | Crystal Structure of Phosphotransferase(9)-Ia Reveals Conformational Change upon Substrate Binding |
Lawandi, Janice | Moitessier, Nicolas | Computer-aided Design, Synthesis and Biological Evaluation of Inhibitors of Prolyl Oligopeptidase Enzyme for the Treatment of Alzheimer’s Disease/Stabilizing Helical Alzheimer’s Ab(1-42) to Prevent its Aggregation, Analyzed by CD |
Maattanen, Veli-Pekka | Thomas, David | Dissecting Key Players in Endoplasmic Reticulum Protein Folding Quality Control: ERp57, PDI, and UGGT and Developing Specific Inhibitors of these Enzymes |
Palmer, Alison | Sleiman, Hanadi | Self-assembly of DNA Nucleoside Analogs into Hexameric Rosettes |
January 2004 | ||
Trainee | Mentor | Research interest |
Soriano, David | Gleason, James | Pseudo-dynamic Combinatorial Library System Miniaturization and Library Expansion |
Sukarieh, Rami | Pelletier, Jerry | In vivo FRET analysis of eIF4E and its repressor |
Welbourn, Sarah | Pause, Arnim | Identification and use of inhibitors for the characterization of the Hepatitis C NS/3 protease |
September 2003 | ||
Trainee | Mentor | Research interest |
Chatain, Guillaume | Bohle, Scott | Towards an Understanding of Hemozoin Formation and Chloroquine Resistance in Plasmodium Falciparum |
Gao, Feng | Auclair, Karine | Synthesis of Bisubstrate Analog Inhibitors for Aminoglycoside 6'-N-Acetyltransferase (AAC6')and their Inhibition |
Pomerantseva, Ekaterina | Gehring, Kalle | Discovery of small molecule ligands of 2',3'-cyclic nucleotide 3'-phosphodiesterase |
Roudaia, Liya | Gallouzi, Imed | Characterization of RasGAP-SH3-binding Protein's in vivo Functions |
Slim, Mohamed | Sleiman, Hanadi | Towards the Protein Mediated Self-Assembly of Discrete DNA Nanostructures into Higher-Order Frameworks |
Spina, Carla | Bohle, Scott | A Novel Application for ZnO Nanoparticles: New Fluorescent Direct Probes for NO |
Stuible, Matthew | Tremblay, Michel | PTP-1B inhibitors: development, modeling and mechanism of action |
Waller, Daniel | Thomas, David | Small Molecule Inhibitors of the Unfolded Protein Response |
January 2003 | ||
Trainee | Mentor | Research interest |
Côté, Cynthia | Auclair, Karine | Design of Molecules to Stabilize the Helical Conformation of the Amyloid-beta Peptide/Differences in the Components and the Biological Activity of Traditional and Commercial Kava Extracts |
Généreux-Vincent, Tobie | Ronis, David | Mesoscopic coarse-grained method for the simulation of protein dynamics using nonlinear response theory |
Jackson, Stephen | Auclair, Karine | Identification of Potential Small Molecules that Can Disaggregate b-Amyloid Plaques |
Mills, John | Pelletier, Jerry | mTOR Deregulation in the Conxtext of the E(mu)-myc Lymphoma Mouse Model |
Mitra, Debbie | Damha, Masad | Development of Novel Template Mediated Strategies in the Chemical Synthesis of Lariat and Branched RNA |
Pâtureau, Bénédicte | Damha, Masad | Induction of RNAse H Activity by Arabinose-Peptide Nucleic Acids |
September 2002 | ||
Trainee | Mentor | Research interest |
Cheesman, Jeremy | Kazlauskas, Romas | Pseudo-Dynamic Combinatorial Libraries |
Donga, Robert | Damha, Masad | Structure and Stability of Nucleoside Phosphotriesters: Toward an Understanding of RNA-X |
Gaudineau, Cedric | Auclair, Karine | Inhibition of Drug Metabolizing P450 Enzymes by Niacin and Ginkgo biloba Extract |
Karam, Jehanne | Saragovi, Uri | Identification of Small Molecules that Bind to and Regulate the Activity of the Neurotrophin Family of Receptors |
Korczynska, Magdalena | Berghuis, Albert | Structure Determination of Streptogramin B Lyase and its Interaction with Small Molecules |
Leung, Stephane | Silvius, John | S-Acylation of Fully Deprotected Peptides using Thioesters as Acyl Donors |
Postgraduate training awarded recipients | ||
September 2006 | ||
Trainee | Mentor | Research interest |
Thielges, Sabine | Moitessier, Nicolas | Investigation of the MBD2 Mechanism of Action to Design and Synthesize New Anticancer Drugs |
September 2005 | ||
Trainee | Mentor | Research interest |
Petrolakis, Emmanuel | Sonenberg, Nahum | Role of the EIF4E Binding Proteins (4E-BPs) in Senescence and Cancer |
January 2005 | ||
Trainee | Mentor | Research interest |
Houston, Douglas | Berghuis, Albert | Structural Studies and Inhibitor Design for Aminoglycoside Phosphotransferases from Pathogenic Bacteria |
September 2004 | ||
Trainee | Mentor | Research interest |
Azzam, Nura | Gehring, Kalle | Small Molecule Inhibitors of the Bcl-2 Pathway as Potential Anti-cancer Agents |
Carlile, Graeme | Thomas, David | Development of a Cell Based Assay System to Investigate the Trafficking of CFTR - Potential for Utilization for HTS Screens |
September 2003 | ||
Trainee | Mentor | Research interest |
Ait-Mohand, Samia | Auclair, Karine | Factors Affecting the Organization of the Amyloid-b(1-42) Peptide and Synthesis of Ligands Stabilizing the Helical Structure of the Peptide |
Cai, Jie | Gros, Philippe | Molecular Characterization of Cellular Resistance to Cytarabine in Leukemia Cells/Transcriptional Profiling Studies to Dissect Resistance Mechanism to Bortezomib (Velcade, PS-341) in Multiple Myeloma Cell Lines |
Ionescu, Andrie | Moitessier, Nicolas / Just, George | QMM/MM Modeling of the methylated-CpG-binding domain 2 (MBD2) protein and drug design of a potential inhibitor |
LeBacquer, Olivier | Sonenberg, Nahum | Role of the 4E-BP Proteins in the Pathogenesis of Obesity and Insulin Resistance |
Perepichka, Inna | Bohle, Scott | New Probes for Diethylcarbamazine’s Antimicrofilarial Drug Action |
Uetani, Noriko | Tremblay, Michel | Chemical and Biological Modulators of Protein Tyrosine Phosphatase Sigma |