/channels/news_feeds/all/term/Article/rss en /channels/channels/news/new-paper-published-today-348790 <div class="field field-name-body field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even"><p>A new <a href="https://www.nature.com/articles/s44172-023-00088-x">paper</a> from my lab is now published online in a Nature paper Today. (Writes Parisa Ariya)</p></div></div></div><div class="field field-name-field-published-date field-type-datestamp field-label-hidden"><div class="field-items"><div class="field-item even"><div class="custom-multi-date"><div class="multi-date first"><span class="label">Published: </span><span class="day">20 </span><span class="month">June </span><span class="year">2023</span></div></div></div></div></div> Tue, 20 Jun 2023 21:21:52 +0000 webfull 190199 at /channels /channels/news/tsabtrizos-and-berghuis-groups-unravel-important-mechanistic-insight-cancer-formation-265270 <div class="field field-name-body field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even"><p>Human farnesyl pyrophosphate synthase (hFPPS) plays a key role in the prenylation of small GTPases, such as RAS and RAP 1A, which are intimately involved in oncogenesis. An allosteric pocket of the enzyme has been of particular interest as a therapeutic target, however, its natural biological function has been (until now) unknown. The teams of Berghuis (Biochemistry) and Tsantrizos (Chemistry) have just reported that the catalytic product of hFPPS, farnesyl pyrophosphate (FPP), bind to this pocket and locks the enzyme in a conformationally inactive state.</p></div></div></div><div class="field field-name-field-primary-image field-type-image field-label-hidden"><div class="field-items"><div class="field-item even"><img class="no-float" src="/channels/files/channels/styles/wysiwyg_medium/public/channels/image/youla_2017.jpg?itok=pakSRYdW" width="160" height="68" /></div></div></div><div class="field field-name-field-published-date field-type-datestamp field-label-hidden"><div class="field-items"><div class="field-item even"><div class="custom-multi-date"><div class="multi-date first"><span class="label">Published: </span><span class="day">21 </span><span class="month">January </span><span class="year">2017</span></div></div></div></div></div> Sat, 21 Jan 2017 18:34:41 +0000 webfull 124291 at /channels