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Fighting brain cancer at its root

±«ÓãÖ±²¥ researchers identify proteins that drive cancer stem cells. Targeting and supressing a particular protein called galectin1 could provide a more effective treatment for glioblastoma, in combination with radiation therapy.

Due to its resistance to therapy, glioblastoma is the most common and aggressive cancerous brain tumour in adults. It grows fast and spreads quickly. While treatments such as surgery, radiation, and chemotherapy can help ease symptoms for a few months, in most cases tumour cells regrow after treatment and the cancer recurs.

Classified as: glioblastoma, brain, Cancer, tumour, treatment, therapy, Arezu Jahani-Asl
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Published on: 31 Aug 2021

Gene targeting helps overcome the resistance of brain cancer to therapy

New insight into a gene that controls energy production in cancer stem cells could help in the search for a more effective treatment for glioblastoma. A ±«ÓãÖ±²¥-led study published in Nature Communications reveals that suppressing the OSMR gene can improve the effectiveness of radiation therapy.

This approach, led by the laboratory of Arezu Jahani-Asl, Assistant Professor of Medicine at ±«ÓãÖ±²¥, was successful in preclinical mouse models where the deletion of the OSMR gene resulted in a significant improvement of tumour response to therapy and expanded lifespan.

Classified as: brain, Cancer, OSMR, Gene, glioblastoma, gene targeting, Arezu Jahani-Asl
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Published on: 17 Aug 2020
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