Jeremy Van Raamsdonk, PhD, MSc
Associate Professor
I use a genetic approach to study the biology of aging and the causative factors involved in neurodegenerative diseases, such as Parkinson's disease and Huntington's disease. My work aims to understand the molecular mechanisms underlying the aging process, and to use the knowledge gained to promote healthy aging and to develop new treatments for neurodegenerative disorders.
Mitochondrial unfolded protein response transcription factor ATFS-1 promotes longevity in a long-lived mitochondrial mutant through activation of stress response pathways. Wu Z, Senchuk MM, Dues DJ, Johnson BK, Cooper JF, Lew L, Machiela E, Schaar CE, DeJonge H, Blackwell TK, Van Raamsdonk JM. BMC Biol. 2018 Dec 18;16(1):147. doi: 10.1186/s12915-018-0615-3. PMID:Â 30563508.
Activation of DAF-16/FOXO by reactive oxygen species contributes to longevity in long-lived mitochondrial mutants in Caenorhabditis elegans. Senchuk MM, Dues DJ, Schaar CE, Johnson BK, Madaj ZB, Bowman MJ, Winn ME, Van Raamsdonk JM. PLoS Genet. 2018 Mar 9;14(3):e1007268. doi: 10.1371/journal.pgen.1007268. eCollection 2018 Mar. PMID:Â 29522556.
Activation of the mitochondrial unfolded protein response promotes longevity and dopamine neuron survival in Parkinson's disease models. Cooper JF, Machiela E, Dues DJ, Spielbauer KK, Senchuk MM, Van Raamsdonk JM. Sci Rep. 2017 Nov 27;7(1):16441. doi: 10.1038/s41598-017-16637-2. PMID:Â 29180793.
Delaying aging is neuroprotective in Parkinson's disease: a genetic analysis in C. elegans models. Cooper JF, Dues DJ, Spielbauer KK, Machiela E, Senchuk MM, Van Raamsdonk JM. NPJ Parkinsons Dis. 2015 Nov 19;1:15022. doi: 10.1038/npjparkd.2015.22. eCollection 2015. PMID:Â 28725688.
Mitochondrial and cytoplasmic ROS have opposing effects on lifespan. Schaar CE, Dues DJ, Spielbauer KK, Machiela E, Cooper JF, Senchuk M, Hekimi S, Van Raamsdonk JM. PLoS Genet. 2015 Feb 11;11(2):e1004972. doi: 10.1371/journal.pgen.1004972. eCollection 2015 Feb. PMID:Â 25671321.